| ID | Name | Quality | Difficulty (after pre-requirements) | Unlock Requirement | Pre-requirements | URL |
|---|---|---|---|---|---|---|
| 0 | Isaac | Neutral | Automatic | Enter the basement | https://bindingofisaacrebirth.wiki.gg/# | |
| 1 | Magdalene | Good | Easy | Have 7 or more Red Heart Containers at one time | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Magdalene |
| 2 | Cain | Good | Easy | Hold 55 Coins at one time | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Cain |
| 3 | Judas | Good | Average difficulty | Defeat Satan | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Judas |
| 4 | The Womb | Neutral | Easy | Defeat Mom | 14 | https://bindingofisaacrebirth.wiki.gg//wiki/Womb |
| 5 | The Harbingers | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Harbingers |
| 6 | A Cube of Meat | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Cube_of_Meat |
| 7 | The Book of Revelations | Great | Easy | Defeat a Harbinger | 5 | https://bindingofisaacrebirth.wiki.gg//wiki/Book_of_Revelations |
| 8 | A Noose | Good | Average difficulty | Defeat Mom's Heart 3 times | 150 | https://bindingofisaacrebirth.wiki.gg//wiki/Transcendence |
| 9 | The Nail | Great | Easy | Complete the Boss Rush as Azazel | 4, 79 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Nail |
| 10 | A Quarter | Bad | Average difficulty | Defeat Mom's Heart 8 times | 141 | https://bindingofisaacrebirth.wiki.gg//wiki/A_Quarter |
| 11 | A Fetus in a Jar | Great | Average difficulty | Defeat Mom's Heart 9 times | 10 | https://bindingofisaacrebirth.wiki.gg//wiki/Dr._Fetus |
| 12 | A Small Rock | Great | Easy | Destroy 100 Tinted Rocks | 28 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Small_Rock |
| 13 | Monstro's Tooth | Bad | Easy | Beat Chapter 1 | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Monstro%27s_Tooth |
| 14 | Lil' Chubby | Neutral | Easy | Beat Chapter 2 | 13 | https://bindingofisaacrebirth.wiki.gg//wiki/Little_Chubby |
| 15 | Loki's Horns | Neutral | Easy | Defeat Lokii | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Loki%27s_Horns |
| 16 | Something From The Future | Neutral | Easy | Beat Basement 40 times | 13 | https://bindingofisaacrebirth.wiki.gg//wiki/Steven |
| 17 | Something Cute | Neutral | Easy | Beat Chapter 2 30 times | 14 | https://bindingofisaacrebirth.wiki.gg//wiki/C.H.A.D. |
| 18 | Something Sticky | Neutral | Easy | Beat Chapter 3 20 times | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Gish |
| 19 | A Bandage | Good | Easy | Make a Super Bandage Girl by picking up 4 copies of Ball of Bandages in one run | 6 | https://bindingofisaacrebirth.wiki.gg//wiki/Super_Bandage |
| 20 | A Cross | Good | Average difficulty | Defeat Isaac as Magdalene | 1, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Relic |
| 21 | A Bag of Pennies | Neutral | Average difficulty | Defeat Isaac as Cain | 2, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Sack_of_Pennies |
| 22 | The Book of Sin | Neutral | Easy | Defeat all 7 Deadly Sins | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Book_of_Sin |
| 23 | Little Gish | Neutral | Easy | Defeat Gish | 18 | https://bindingofisaacrebirth.wiki.gg//wiki/Little_Gish |
| 24 | Little Steven | Neutral | Easy | Defeat Steven | 16 | https://bindingofisaacrebirth.wiki.gg//wiki/Little_Steven |
| 25 | Little C.H.A.D | Neutral | Easy | Defeat C.H.A.D. | 17 | https://bindingofisaacrebirth.wiki.gg//wiki/Little_C.H.A.D. |
| 26 | A Gamekid | Neutral | Easy | Visit 10 Arcades | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Gamekid |
| 27 | A Halo | Neutral | Easy | Defeat Mom, Mom's Heart, or It Lives! using The Bible or XV - The Devil? | 14 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Halo |
| 28 | Mr. Mega | Good | Easy | Destroy 10 Tinted Rocks | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Mr._Mega |
| 29 | The D6 | Epic | Average difficulty | Defeat Isaac as ??? | 32 | https://bindingofisaacrebirth.wiki.gg//wiki/The_D6 |
| 30 | The Scissors | Neutral | Easy | Die 100 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Death |
| 31 | The Parasite | Good | Easy | Pick up any 2 items that have the 'dead' item tag in a single run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Parasite |
| 32 | ??? | Neutral | Average difficulty | Defeat Mom's Heart 10 times | 11 | https://bindingofisaacrebirth.wiki.gg//wiki/%3F%3F%3F_(Character) |
| 33 | Everything Is Terrible!!! | Bad | Average difficulty | Defeat Mom's Heart 5 times | 139 | https://bindingofisaacrebirth.wiki.gg/# |
| 34 | It Lives! | Good | Average difficulty | Defeat Mom's Heart 11 times | 32 | https://bindingofisaacrebirth.wiki.gg//wiki/It_Lives |
| 35 | Mom's Contact | Great | Easy | Obtain three Yes Mother? items in one run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Mom%27s_Contacts |
| 36 | The Necronomicon | Neutral | Easy | Use XIII - Death 4 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Necronomicon |
| 37 | Basement Boy | Neutral | Easy | Beat Chapter 1 without taking damage | 0 | https://bindingofisaacrebirth.wiki.gg/# |
| 38 | Spelunker Boy | Neutral | Easy | Beat Chapter 2 without taking damage | 13 | https://bindingofisaacrebirth.wiki.gg/# |
| 39 | Dark Boy | Neutral | Easy | Beat Chapter 3 without taking damage | 14 | https://bindingofisaacrebirth.wiki.gg/# |
| 40 | Mama's Boy | Neutral | Average difficulty | Beat Chapter 4 without taking damage | 81 | https://bindingofisaacrebirth.wiki.gg/# |
| 41 | Golden God! | Neutral | Average difficulty | Defeat ??? and The Lamb | 57, 78 | https://bindingofisaacrebirth.wiki.gg/# |
| 42 | Eve | Good | Easy | Don't pick up any Hearts for 2 floors in a row | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Eve |
| 43 | Mom's Knife | Epic | Average difficulty | Defeat Satan as Isaac | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Mom%27s_Knife |
| 44 | The Razor | Bad | Average difficulty | Defeat Satan as Eve | 42, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Razor_Blade |
| 45 | Guardian Angel | Neutral | Average difficulty | Defeat Satan as Magdalene | 1, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Guardian_Angel |
| 46 | A Bag of Bombs | Neutral | Average difficulty | Defeat Satan as Cain | 2, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Bomb_Bag |
| 47 | Demon Baby | Bad | Average difficulty | Defeat The Lamb as Azazel | 78, 127 | https://bindingofisaacrebirth.wiki.gg//wiki/Demon_Baby |
| 48 | Forget Me Now | Great | Average difficulty | Defeat Satan as ??? | 32 | https://bindingofisaacrebirth.wiki.gg//wiki/Forget_Me_Now |
| 49 | The D20 | Good | Average difficulty | Defeat ??? as Isaac | 57, 106 | https://bindingofisaacrebirth.wiki.gg//wiki/D20 |
| 50 | Celtic Cross | Neutral | Average difficulty | Defeat ??? as Magdalene | 20, 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Celtic_Cross |
| 51 | Abel | Bad | Average difficulty | Defeat ??? as Cain | 46, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Abel |
| 52 | Curved Horn | Great | Average difficulty | Defeat The Lamb as Judas | 72, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Curved_Horn |
| 53 | Sacrificial Dagger | Good | Average difficulty | Defeat ??? as Eve | 76, 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Sacrificial_Dagger |
| 54 | Bloody Lust | Neutral | Average difficulty | Defeat Isaac as Samson | 67, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Bloody_Lust |
| 55 | Blood Penny | Neutral | Average difficulty | Defeat ??? as Samson | 54, 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Bloody_Penny |
| 56 | Blood Rights | Bad | Average difficulty | Defeat Satan as Samson | 67, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Blood_Rights |
| 57 | The Polaroid | Good | Average difficulty | Defeat Isaac 5 times | 33 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Polaroid |
| 58 | Dad's Key | Neutral | Easy | Pick up both Key Pieces from the Angels in one run | 370 | https://bindingofisaacrebirth.wiki.gg//wiki/Dad%27s_Key |
| 59 | Blue Candle | Neutral | Easy | Donate 900 coins to the Donation Machine | 154 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Candle |
| 60 | Burnt Penny | Good | Hard | Complete Beans! (challenge #13) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Burnt_Penny |
| 61 | Lucky Toe | Good | Easy | Blow up 20 Shopkeepers | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Lucky_Toe |
| 62 | Epic Fetus | Epic | Insanely hard | Complete The Family Man (challenge #19) | 165 | https://bindingofisaacrebirth.wiki.gg//wiki/Epic_Fetus |
| 63 | SMB Super Fan | Good | Average difficulty | Complete It's in the Cards (challenge #14) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/SMB_Super_Fan |
| 64 | Counterfeit Coin | Good | Easy | Play either Shell Game or Hell Game 100 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Counterfeit_Penny |
| 65 | Guppy's Hairball | Good | Easy | Become Guppy | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Guppy%27s_Hairball |
| 66 | A Forgotten Horseman | Neutral | Easy | Take 10 Angel Room items | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Conquest |
| 67 | Samson | Good | Easy | Complete 2 floors in a row without taking damage | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Samson |
| 68 | Something Icky | Neutral | Average difficulty | Defeat Isaac 10 times | 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Triachnid |
| 69 | !Platinum God! | Neutral | Hard | Collect all non-DLC items in the game, and unlock all of the secrets and endings (minus The Lost and his 6 unlockable items) | 7, 9, 12, 19, 22, 23, 24, 25, 26, 27, 30, 31, 35, 36, 37, 38, 39, 40, 41, 47, 49, 50, 51, 52, 55, 60, 61, 63, 64, 66, 68, 70, 71, 73, 74, 75, 77, 83, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 108, 109, 110, 111, 112, 113, 114, 115, 118, 119, 120, 121, 122, 123, 124, 125, 128, 138, 143, 144, 145, 146, 147, 148, 149, 167, 168, 169, 170, 171, 172, 173, 174, 176, 177, 178 | https://bindingofisaacrebirth.wiki.gg/# |
| 70 | Isaac's Head | Neutral | Average difficulty | Complete the Boss Rush as Isaac | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Isaac%27s_Head |
| 71 | Maggy's Faith | Good | Average difficulty | Defeat The Lamb as Magdalene | 45, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Maggy%27s_Faith |
| 72 | Judas' Tongue | Good | Average difficulty | Defeat Satan as Judas | 3 | https://bindingofisaacrebirth.wiki.gg//wiki/Judas%27_Tongue |
| 73 | ???'s Soul | Neutral | Average difficulty | Defeat The Lamb as ??? | 48, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/%3F%3F%3F%27s_Soul |
| 74 | Samson's Lock | Good | Average difficulty | Defeat The Lamb as Samson | 56, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Samson%27s_Lock |
| 75 | Cain's Eye | Good | Average difficulty | Defeat ??? as Cain | 21, 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Cain%27s_Eye |
| 76 | Eve's Bird Foot | Neutral | Average difficulty | Defeat Isaac as Eve | 42, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Eve%27s_Bird_Foot |
| 77 | The Left Hand | Neutral | Average difficulty | Defeat Ultra Pride as any character, or ??? as Judas | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Left_Hand |
| 78 | The Negative | Good | Average difficulty | Defeat Satan 5 times | 33 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Negative |
| 79 | Azazel | Great | Easy | Make 3 Deals with the Devil in one run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Azazel |
| 80 | Lazarus | Good | Easy | Have 4 or more Soul Hearts at one time | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Lazarus |
| 81 | Eden | Good | Easy | Complete Chapter 4 | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Eden |
| 82 | The Lost | Neutral | Easy | Die in a Sacrifice Room while holding Missing Poster | 149 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Lost |
| 83 | Dead Boy | Neutral | Average difficulty | Complete Chapter 6 without taking damage | 33 | https://bindingofisaacrebirth.wiki.gg/# |
| 84 | The Real Platinum God | Neutral | Hard | Collect every non-DLC item, and unlock every secret and ending. | 69, 156 | https://bindingofisaacrebirth.wiki.gg//wiki/Collection_Page |
| 85 | Lucky Rock | Good | Easy | Destroy 100 rocks | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Lucky_Rock |
| 86 | The Cellar | Neutral | Easy | Beat all Basement bosses (except Baby Plum) (not restricted to beating bosses in The Basement) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Cellar |
| 87 | The Catacombs | Neutral | Easy | Beat all Caves bosses (except Bumbino) (not restricted to beating bosses in The Caves) | 13 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Catacombs |
| 88 | The Necropolis | Neutral | Easy | Beat all Depths bosses (except Reap Creep) (not restricted to beating bosses in The Depths) | 14 | https://bindingofisaacrebirth.wiki.gg//wiki/Necropolis |
| 89 | Rune of Hagalaz | Neutral | Easy | Complete Pitch Black (challenge #1) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 90 | Rune of Jera | Great | Average difficulty | Complete High Brow (challenge #2) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 91 | Rune of Ehwaz | Good | Hard | Complete Head Trauma (challenge #3) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 92 | Rune of Dagaz | Good | Average difficulty | Complete Darkness Falls (challenge #4) | 157 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 93 | Rune of Ansuz | Good | Average difficulty | Complete The Tank (challenge #5) | 158 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 94 | Rune of Perthro | Great | Hard | Complete Solar System (challenge #6) | 159 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 95 | Rune of Berkano | Bad | Hard | Complete Purist (challenge #20) | 166 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 96 | Rune of Algiz | Great | Hard | Complete Cat Got Your Tongue (challenge #8) | 161 | https://bindingofisaacrebirth.wiki.gg//wiki/Runes |
| 97 | Chaos Card | Great | Average difficulty | Complete Demo Man (challenge #9) | 162 | https://bindingofisaacrebirth.wiki.gg//wiki/Chaos_Card |
| 98 | Credit Card | Good | Average difficulty | Complete Cursed! (challenge #10) | 163 | https://bindingofisaacrebirth.wiki.gg//wiki/Credit_Card |
| 99 | Rules Card | Terrible | Average difficulty | Complete Glass Cannon (challenge #11) | 164 | https://bindingofisaacrebirth.wiki.gg//wiki/Rules_Card |
| 100 | Card Against Humanity | Good | Average difficulty | Complete When Life Gives You Lemons (challenge #12) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/A_Card_Against_Humanity |
| 101 | Swallowed Penny | Good | Easy | Complete Slow Roll (challenge #15) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Swallowed_Penny |
| 102 | Robo-Baby 2.0 | Neutral | Easy | Complete Computer Savvy (challenge #16) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Robo-Baby_2.0 |
| 103 | Death's Touch | Great | Hard | Complete Waka Waka (challenge #17) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Death%27s_Touch |
| 104 | Technology .5 | Good | Average difficulty | Complete The Host (challenge #18) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Tech.5 |
| 105 | Missing No. | Bad | Average difficulty | Complete the Boss Rush as Lazarus | 4, 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Missing_No. |
| 106 | Isaac's Tears | Bad | Average difficulty | Defeat Isaac as Isaac | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Isaac%27s_Tears |
| 107 | Guillotine | Bad | Average difficulty | Defeat Isaac as Judas | 3 | https://bindingofisaacrebirth.wiki.gg//wiki/Guillotine |
| 108 | Judas' Shadow | Good | Average difficulty | Complete the Boss Rush as Judas | 3 | https://bindingofisaacrebirth.wiki.gg//wiki/Judas%27_Shadow |
| 109 | Maggy's Bow | Neutral | Average difficulty | Complete the Boss Rush as Magdalene | 1, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Maggy%27s_Bow |
| 110 | Cain's Other Eye | Good | Average difficulty | Complete the Boss Rush as Cain | 2, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Cain%27s_Other_Eye |
| 111 | Black Lipstick | Good | Average difficulty | Defeat The Lamb as Eve | 44, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Black_Lipstick |
| 112 | Eve's Mascara | Great | Average difficulty | Complete the Boss Rush as Eve | 4, 42 | https://bindingofisaacrebirth.wiki.gg//wiki/Eve%27s_Mascara |
| 113 | Fate | Good | Average difficulty | Defeat ??? as ??? | 29, 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Fate |
| 114 | ???'s Only Friend | Neutral | Average difficulty | Complete the Boss Rush as ??? | 32 | https://bindingofisaacrebirth.wiki.gg//wiki/%3F%3F%3F%27s_Only_Friend |
| 115 | Samson's Chains | Neutral | Average difficulty | Complete the Boss Rush as Samson | 4, 67 | https://bindingofisaacrebirth.wiki.gg//wiki/Samson%27s_Chains |
| 116 | Lazarus' Rags | Bad | Average difficulty | Defeat Isaac as Lazarus | 80, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Lazarus%27_Rags |
| 117 | Broken Ankh | Bad | Average difficulty | Defeat Satan as Lazarus | 80, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Broken_Ankh |
| 118 | Store Credit | Good | Average difficulty | Defeat ??? as Lazarus | 57, 116 | https://bindingofisaacrebirth.wiki.gg//wiki/Store_Credit |
| 119 | Pandora's Box | Good | Average difficulty | Defeat The Lamb as Lazarus | 117, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Pandora%27s_Box |
| 120 | Suicide King | Bad | Insanely hard | Complete Suicide King (challenge #7) | 160 | https://bindingofisaacrebirth.wiki.gg//wiki/Suicide_King |
| 121 | Blank Card | Great | Average difficulty | Defeat Isaac as Eden | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Blank_Card |
| 122 | Book of Secrets | Neutral | Average difficulty | Defeat Satan as Eden | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Book_of_Secrets |
| 123 | Mysterious Paper | Neutral | Average difficulty | Defeat ??? as Eden | 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Mysterious_Paper |
| 124 | Mystery Sack | Neutral | Average difficulty | Defeat The Lamb as Eden | 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Mystery_Sack |
| 125 | Undefined | Neutral | Average difficulty | Complete the Boss Rush as Eden | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Undefined |
| 126 | Satanic Bible | Great | Average difficulty | Defeat Isaac as Azazel | 79, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Satanic_Bible |
| 127 | Daemon's Tail | Good | Average difficulty | Defeat Satan as Azazel | 79, 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Daemon%27s_Tail |
| 128 | Abaddon | Great | Average difficulty | Defeat ??? as Azazel | 57, 126 | https://bindingofisaacrebirth.wiki.gg//wiki/Abaddon |
| 129 | Isaac's Heart | Neutral | Hard | Defeat Isaac as The Lost | 82 | https://bindingofisaacrebirth.wiki.gg//wiki/Isaac%27s_Heart |
| 130 | The Mind | Great | Hard | Defeat Satan as The Lost | 82 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Mind |
| 131 | The Body | Great | Hard | Defeat ??? as The Lost | 57, 129 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Body |
| 132 | The Soul | Great | Hard | Defeat The Lamb as The Lost | 130 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Soul |
| 133 | The D100 | Neutral | Hard | Complete the Boss Rush as The Lost | 82 | https://bindingofisaacrebirth.wiki.gg//wiki/D100 |
| 134 | Blue Map | Good | Easy | Donate 10 Coins to the Donation Machine | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Blue_Map |
| 135 | There's Options | Great | Easy | Donate 50 Coins to the Donation Machine | 151 | https://bindingofisaacrebirth.wiki.gg//wiki/There%27s_Options |
| 136 | Black Candle | Great | Easy | Donate 150 Coins to the Donation Machine | 152 | https://bindingofisaacrebirth.wiki.gg//wiki/Black_Candle |
| 137 | Red Candle | Good | Easy | Donate 400 Coins to the Donation Machine | 153 | https://bindingofisaacrebirth.wiki.gg//wiki/Red_Candle |
| 138 | Stop Watch | Great | Easy | Donate 999 Coins to the Donation Machine | 59 | https://bindingofisaacrebirth.wiki.gg//wiki/Stop_Watch |
| 139 | Wire Coat Hanger | Good | Average difficulty | Defeat Mom's Heart 4 times | 8 | https://bindingofisaacrebirth.wiki.gg//wiki/Wire_Coat_Hanger |
| 140 | Ipecac | Great | Average difficulty | Defeat Mom's Heart 6 times | 33 | https://bindingofisaacrebirth.wiki.gg//wiki/Ipecac |
| 141 | Experimental Treatment | Bad | Average difficulty | Defeat Mom's Heart 7 times | 140 | https://bindingofisaacrebirth.wiki.gg//wiki/Experimental_Treatment |
| 142 | Krampus | Bad | Easy | Take 20 items from Devil Rooms | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Krampus |
| 143 | Head of Krampus | Neutral | Easy | Defeat Krampus | 142 | https://bindingofisaacrebirth.wiki.gg//wiki/Head_of_Krampus |
| 144 | Super Meat Boy | Neutral | Easy | Make a Super Meat Boy by picking up 4 copies of Cube of Meat in one run | 6 | https://bindingofisaacrebirth.wiki.gg//wiki/Cube_of_Meat |
| 145 | Butter Bean | Bad | Easy | Destroy 100 Poops | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Butter_Bean |
| 146 | Little Baggy | Bad | Easy | Pick up any 2 items that have the 'syringe' item tag in a single run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Little_Baggy |
| 147 | Blood Bag | Good | Easy | Use the Blood Donation Machine 30 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Blood_Bag |
| 148 | The D4 | Neutral | Easy | Blow up 30 Slot Machine | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/D4 |
| 149 | Missing Poster | Neutral | Easy | Defeat The Lamb as Isaac | 43, 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Missing_Poster |
| 150 | Rubber Cement | Good | Average difficulty | Defeat Mom's Heart 2 times | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Rubber_Cement |
| 151 | Store Upgrade lv.1 | Good | Easy | Donate 20 Coins to the Donation Machine | 134 | https://bindingofisaacrebirth.wiki.gg//wiki/Shop#Levels |
| 152 | Store Upgrade lv.2 | Good | Easy | Donate 100 Coins to the Donation Machine | 135 | https://bindingofisaacrebirth.wiki.gg//wiki/Shop#Levels |
| 153 | Store Upgrade lv.3 | Good | Easy | Donate 200 Coins to the Donation Machine | 136 | https://bindingofisaacrebirth.wiki.gg//wiki/Shop#Levels |
| 154 | Store Upgrade lv.4 | Good | Easy | Donate 600 Coins to the Donation Machine | 137 | https://bindingofisaacrebirth.wiki.gg//wiki/Shop#Levels |
| 155 | Angels | Good | Average difficulty | Complete Chapter 6 | 33 | https://bindingofisaacrebirth.wiki.gg//wiki/Angel |
| 156 | Godhead | Epic | Automatic | Earn all 12 Completion Marks on Hard mode as The Lost | 131, 132, 133, 175, 189, 215, 293, 307, 460, 461 | https://bindingofisaacrebirth.wiki.gg//wiki/Godhead |
| 157 | Darkness Falls | Neutral | Automatic | Defeat Mom's Heart 11 times and defeat ??? as Eve | 34, 53 | https://bindingofisaacrebirth.wiki.gg//wiki/Darkness_Falls |
| 158 | The Tank | Neutral | Automatic | Have 7 or more Red Heart Containers at one time | 1 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Tank |
| 159 | Solar System | Neutral | Automatic | Defeat Mom's Heart 3 times | 8 | https://bindingofisaacrebirth.wiki.gg//wiki/Solar_System |
| 160 | Suicide King | Neutral | Automatic | Defeat Mom's Heart 11 times and unlock Lazarus | 34, 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Suicide_King_(Challenge) |
| 161 | Cat Got Your Tongue | Neutral | Automatic | Become Guppy | 65 | https://bindingofisaacrebirth.wiki.gg//wiki/Cat_Got_Your_Tongue |
| 162 | Demo Man | Neutral | Automatic | Defeat Mom's Heart 9 times | 11 | https://bindingofisaacrebirth.wiki.gg//wiki/Demo_Man |
| 163 | Cursed! | Neutral | Automatic | Have 7 or more Red Heart Containers at one time | 1 | https://bindingofisaacrebirth.wiki.gg//wiki/Cursed! |
| 164 | Glass Cannon | Neutral | Automatic | Beat The Family Man (challenge #19), defeat Lokii, and unlock Judas | 3, 15, 62 | https://bindingofisaacrebirth.wiki.gg//wiki/Glass_Cannon_(Challenge) |
| 165 | The Family Man | Neutral | Automatic | Pick up both Key Pieces from the Angels in one run | 58 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Family_Man |
| 166 | Purist | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Purist |
| 167 | Lost Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Isaac | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 168 | Cute Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Magdalene | 1, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 169 | Crow Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Eve | 42, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 170 | Shadow Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Judas | 3 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 171 | Glass Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Cain | 2, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 172 | Wrapped Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Lazarus | 80, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 173 | Begotten Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Azazel | 79, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 174 | Dead Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as ??? | 32 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 175 | -0- Baby | Neutral | Hard | Defeat Mom's Heart on Hard mode as The Lost | 82 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 176 | Glitch Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Eden | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 177 | Fighting Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Samson | 67, 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 178 | Lord of the Flies | Neutral | Easy | Become Beelzebub | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Beelzebub |
| 179 | Fart Baby | Neutral | Average difficulty | Defeat Hush as Isaac | 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Farting_Baby |
| 180 | Purity | Good | Average difficulty | Defeat Hush as Magdalene | 1, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Purity |
| 181 | D12 | Bad | Average difficulty | Defeat Hush as Cain | 2, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/D12 |
| 182 | Detrayal | Neutral | Average difficulty | Defeat Hush as Judas | 3, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Betrayal |
| 183 | Fate's Reward | Good | Average difficulty | Defeat Hush as ??? | 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Fate%27s_Reward |
| 184 | Athame | Great | Average difficulty | Defeat Hush as Eve | 42, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Athame |
| 185 | Blind Rage | Good | Average difficulty | Defeat Hush as Samson | 67, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Blind_Rage |
| 186 | Maw of the Void | Great | Average difficulty | Defeat Hush as Azazel | 79, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Maw_Of_The_Void |
| 187 | Empty Vessel | Good | Average difficulty | Defeat Hush as Lazarus | 80, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Empty_Vessel |
| 188 | Eden's Blessing | Good | Average difficulty | Defeat Hush as Eden | 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Eden%27s_Blessing |
| 189 | Sworn Protector | Good | Insanely hard | Defeat Hush as The Lost | 82, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Sworn_Protector |
| 190 | Incubus | Great | Average difficulty | Defeat Hush as Lilith | 199, 234 | https://bindingofisaacrebirth.wiki.gg//wiki/Incubus |
| 191 | Keeper now holds... A Penny! | Great | Hard | Defeat Hush as Keeper | 234, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper |
| 192 | Lil' Chest | Neutral | Average difficulty | Defeat Ultra Greed as Isaac | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Lil_Chest |
| 193 | Censer | Neutral | Average difficulty | Defeat Ultra Greed as Magdalene | 1 | https://bindingofisaacrebirth.wiki.gg//wiki/Censer |
| 194 | Evil Eye | Good | Average difficulty | Defeat Ultra Greed as Cain | 2 | https://bindingofisaacrebirth.wiki.gg//wiki/Evil_Eye |
| 195 | My Shadow | Bad | Average difficulty | Defeat Ultra Greed as Judas | 3 | https://bindingofisaacrebirth.wiki.gg//wiki/My_Shadow |
| 196 | Cracked Dice | Neutral | Average difficulty | Defeat Ultra Greed as ??? | 32 | https://bindingofisaacrebirth.wiki.gg//wiki/Cracked_Dice |
| 197 | Black Feather | Good | Average difficulty | Defeat Ultra Greed as Eve | 42 | https://bindingofisaacrebirth.wiki.gg//wiki/Black_Feather |
| 198 | Lusty Blood | Great | Average difficulty | Defeat Ultra Greed as Samson | 67 | https://bindingofisaacrebirth.wiki.gg//wiki/Lusty_Blood |
| 199 | Lilith | Good | Average difficulty | Defeat Ultra Greed as Azazel | 79 | https://bindingofisaacrebirth.wiki.gg//wiki/Lilith |
| 200 | Key Bum | Good | Average difficulty | Defeat Ultra Greed as Lazarus | 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Key_Bum |
| 201 | GB Bug | Neutral | Average difficulty | Defeat Ultra Greed as Eden | 81 | https://bindingofisaacrebirth.wiki.gg//wiki/GB_Bug |
| 202 | Zodiac | Bad | Hard | Defeat Ultra Greed as The Lost | 82 | https://bindingofisaacrebirth.wiki.gg//wiki/Zodiac |
| 203 | Box of Friends | Bad | Average difficulty | Defeat Ultra Greed as Lilith | 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Box_of_Friends |
| 204 | Rib of Greed | Good | Hard | Defeat Ultra Greed as Keeper | 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Rib_of_Greed |
| 205 | Cry Baby | Neutral | Average difficulty | Defeat Mega Satan as Isaac | 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 206 | Red Baby | Neutral | Average difficulty | Defeat Mega Satan as Magdalene | 1, 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 207 | Green Baby | Neutral | Average difficulty | Defeat Mega Satan as Cain | 2, 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 208 | Brown Baby | Neutral | Average difficulty | Defeat Mega Satan as Judas | 3, 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 209 | Blue Baby | Neutral | Average difficulty | Defeat Mega Satan as ??? | 32, 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 210 | Lil' Baby | Neutral | Average difficulty | Defeat Mega Satan as Eve | 42, 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 211 | Rage Baby | Neutral | Average difficulty | Defeat Mega Satan as Samson | 58, 67 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 212 | Black Baby | Neutral | Average difficulty | Defeat Mega Satan as Azazel | 58, 79 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 213 | Long Baby | Neutral | Average difficulty | Defeat Mega Satan as Lazarus | 58, 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 214 | Yellow Baby | Neutral | Average difficulty | Defeat Mega Satan as Eden | 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 215 | White Baby | Neutral | Average difficulty | Defeat Mega Satan as The Lost | 58, 82 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 216 | Big Baby | Neutral | Average difficulty | Defeat Mega Satan as Lilith | 58, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 217 | Noose Baby | Neutral | Average difficulty | Defeat Mega Satan as Keeper | 58, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 218 | Rune Bag | Great | Average difficulty | Defeat Isaac as Lilith | 81, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Rune_Bag |
| 219 | Cambion Conception | Bad | Average difficulty | Defeat ??? as Lilith | 57, 218 | https://bindingofisaacrebirth.wiki.gg//wiki/Cambion_Conception |
| 220 | Serpent's Kiss | Good | Average difficulty | Defeat Satan as Lilith | 81, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Serpent%27s_Kiss |
| 221 | Succubus | Good | Average difficulty | Defeat The Lamb as Lilith | 78, 220 | https://bindingofisaacrebirth.wiki.gg//wiki/Succubus |
| 222 | Immaculate Conception | Bad | Average difficulty | Complete the Boss Rush as Lilith | 4, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Immaculate_Conception |
| 223 | Goat Head Baby | Neutral | Average difficulty | Defeat Mom's Heart on Hard mode as Lilith | 4, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 224 | Gold Heart | Good | Average difficulty | Complete XXXXXXXXL (challenge #21) | 265 | https://bindingofisaacrebirth.wiki.gg//wiki/Hearts |
| 225 | Get out of Jail Free Card | Good | Insanely hard | Complete SPEED! (challenge #22) | 266 | https://bindingofisaacrebirth.wiki.gg//wiki/Get_out_of_Jail_Free_Card |
| 226 | Gold Bomb | Epic | Hard | Complete Blue Bomber (challenge #23) | 267 | https://bindingofisaacrebirth.wiki.gg//wiki/Gold_Bomb |
| 227 | 2 new pills | Bad | Hard | Complete PAY TO PLAY (challenge #24) | 268 | https://bindingofisaacrebirth.wiki.gg//wiki/Percs! |
| 228 | 2 new pills | Bad | Average difficulty | Complete Have a Heart (challenge #25) | 269 | https://bindingofisaacrebirth.wiki.gg//wiki/Re-Lax |
| 229 | Poker Chip | Neutral | Average difficulty | Complete I RULE! (challenge #26) | 270 | https://bindingofisaacrebirth.wiki.gg//wiki/Poker_Chip |
| 230 | Stud Finder | Good | Insanely hard | Complete BRAINS! (challenge #27) | 271 | https://bindingofisaacrebirth.wiki.gg//wiki/Stud_Finder |
| 231 | D8 | Good | Average difficulty | Complete PRIDE DAY! (challenge #28) | 272 | https://bindingofisaacrebirth.wiki.gg//wiki/D8 |
| 232 | Kidney Stone | Good | Hard | Complete Onan's Streak (challenge #29) | 273 | https://bindingofisaacrebirth.wiki.gg//wiki/Kidney_Stone |
| 233 | Blank Rune | Great | Hard | Complete The Guardian (challenge #30) | 274 | https://bindingofisaacrebirth.wiki.gg//wiki/Blank_Rune_(Achievement) |
| 234 | Blue Womb | Good | Average difficulty | Defeat Mom's Heart 10 times | 32 | https://bindingofisaacrebirth.wiki.gg//wiki/Blue_Womb |
| 235 | 1001% | Neutral | Automatic | Unlock as many of the previously mentioned things as there were in Afterbirth | 0 | https://bindingofisaacrebirth.wiki.gg/# |
| 236 | Keeper holds Wooden Nickel | Good | Hard | Defeat Isaac as Keeper | 81, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper |
| 237 | Keeper holds Store Key | Good | Hard | Defeat Satan as Keeper | 81, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper |
| 238 | Deep Pockets | Good | Hard | Defeat ??? as Keeper | 57, 236 | https://bindingofisaacrebirth.wiki.gg//wiki/Deep_Pockets |
| 239 | Karma | Good | Hard | Defeat The Lamb as Keeper | 78, 237 | https://bindingofisaacrebirth.wiki.gg//wiki/Karma |
| 240 | Sticky Nickels | Terrible | Hard | Complete the Boss Rush as Keeper | 4, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Sticky_nickel |
| 241 | Super Greed Baby | Neutral | Hard | Defeat Mom's Heart on Hard mode as Keeper | 4, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 242 | Lucky Pennies | Great | Easy | Donate 2 Coins to the Greed Donation Machine | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Lucky_penny |
| 243 | Special Hanging Shopkeepers | Neutral | Easy | Donate 14 Coins to the Greed Donation Machine | 242 | https://bindingofisaacrebirth.wiki.gg//wiki/Special_shopkeeper |
| 244 | Wooden Nickel | Neutral | Easy | Donate 33 Coins to the Greed Donation Machine | 243 | https://bindingofisaacrebirth.wiki.gg//wiki/Wooden_Nickel |
| 245 | Cain holds Paperclip | Great | Easy | Donate 68 Coins to the Greed Donation Machine | 244 | https://bindingofisaacrebirth.wiki.gg//wiki/Cain |
| 246 | Everything is Terrible 2!!! | Bad | Average difficulty | Donate 111 Coins to the Greed Donation Machine | 245 | https://bindingofisaacrebirth.wiki.gg//wiki/Ultra_Greed |
| 247 | Special Shopkeepers | Neutral | Average difficulty | Donate 234 Coins to the Greed Donation Machine | 246 | https://bindingofisaacrebirth.wiki.gg//wiki/Special_shopkeeper |
| 248 | Eve now holds Razor Blade | Great | Average difficulty | Donate 439 Coins to the Greed Donation Machine | 247 | https://bindingofisaacrebirth.wiki.gg//wiki/Eve |
| 249 | Store Key | Good | Average difficulty | Donate 666 Coins to the Greed Donation Machine | 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Store_Key |
| 250 | Lost holds Holy Mantle | Epic | Average difficulty | Donate 879 Coins to the Greed Donation Machine | 249 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Lost |
| 251 | Keeper | Good | Easy | Donate 1000 Coins to the Greed Donation Machine | 275 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper |
| 252 | Hive Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as ??? | 73, 113, 114, 174, 183, 209, 286, 300, 448, 449 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 253 | Buddy Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Isaac | 44, 50, 70, 106, 149, 167, 179, 205, 282, 296, 440, 441 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 254 | Colorful Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Magdalene | 50, 71, 109, 168, 180, 206, 283, 297, 442, 443 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 255 | Whore Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Eve | 53, 111, 112, 169, 184, 210, 288, 302, 450, 451 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 256 | Cracked Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Eden | 121, 122, 123, 124, 125, 176, 188, 214, 289, 303, 458, 459 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 257 | Dripping Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Lazarus | 105, 118, 119, 172, 187, 213, 291, 305, 456, 457 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 258 | Blinding Baby | Neutral | Easy | Use Blank Card while holding XIX - The Sun | 121 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 259 | Sucky Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Azazel | 9, 47, 128, 173, 186, 212, 290, 304, 454, 455 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 260 | Dark Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Lilith | 190, 216, 219, 221, 222, 223, 292, 306, 462, 463 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 261 | Picky Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Cain | 51, 75, 110, 171, 181, 207, 284, 298, 444, 445 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 262 | Revenge Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Samson | 55, 74, 115, 177, 185, 211, 287, 301, 452, 453 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 263 | Belial Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Judas | 52, 77, 107, 108, 170, 182, 208, 285, 299, 446, 447 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 264 | Sale Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Keeper | 191, 217, 238, 239, 240, 241, 294, 308, 464, 465 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 265 | XXXXXXXXL | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/XXXXXXXXL |
| 266 | SPEED! | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/SPEED! |
| 267 | Blue Bomber | Neutral | Automatic | Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times | 34, 28 | https://bindingofisaacrebirth.wiki.gg//wiki/Blue_Bomber |
| 268 | PAY TO PLAY | Neutral | Automatic | Defeat Isaac as Cain and destroy 10 Tinted Rocks | 21, 28 | https://bindingofisaacrebirth.wiki.gg//wiki/PAY_TO_PLAY |
| 269 | Have a Heart | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Have_a_Heart |
| 270 | I RULE! | Neutral | Average difficulty | Defeat Mega Satan and unlock The Negative | 57, 58 | https://bindingofisaacrebirth.wiki.gg//wiki/I_RULE! |
| 271 | BRAINS! | Neutral | Automatic | Defeat Isaac 5 times | 57 | https://bindingofisaacrebirth.wiki.gg//wiki/BRAINS! |
| 272 | PRIDE DAY! | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/PRIDE_DAY! |
| 273 | Onan's Streak | Neutral | Automatic | Unlock Judas and It Lives | 3, 34 | https://bindingofisaacrebirth.wiki.gg//wiki/Onan%27s_Streak |
| 274 | The Guardian | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Guardian |
| 275 | Generosity | Neutral | Hard | Generosity | 250 | https://bindingofisaacrebirth.wiki.gg//wiki/Greed_machine |
| 276 | Mega | Epic | Automatic | Defeat Mega Satan as every character (except Tainted characters) | 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 317, 403, 427, 439 | https://bindingofisaacrebirth.wiki.gg//wiki/Mega_Blast |
| 277 | Backasswards | Neutral | Automatic | Defeat Mega Satan and unlock The Negative | 270 | https://bindingofisaacrebirth.wiki.gg//wiki/Backasswards |
| 278 | Aprils fool | Neutral | Automatic | Defeat Mom | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Aprils_Fool |
| 279 | Pokey Mans | Neutral | Automatic | Defeat Mom's Heart 11 times | 34 | https://bindingofisaacrebirth.wiki.gg//wiki/Pokey_Mans |
| 280 | Ultra Hard | Neutral | Automatic | Defeat Mega Satan and unlock The Negative | 270 | https://bindingofisaacrebirth.wiki.gg//wiki/Ultra_Hard |
| 281 | PONG | Neutral | Automatic | Defeat Isaac 5 times | 57 | https://bindingofisaacrebirth.wiki.gg//wiki/Pong |
| 282 | D infinity | Epic | Average difficulty | Defeat Delirium as Isaac | 320 | https://bindingofisaacrebirth.wiki.gg//wiki/D_infinity |
| 283 | Eucharist | Great | Average difficulty | Defeat Delirium as Magdalene | 1, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Eucharist |
| 284 | Silver Dollar | Good | Average difficulty | Defeat Delirium as Cain | 2, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Silver_Dollar |
| 285 | Shade | Bad | Average difficulty | Defeat Delirium as Judas | 3, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Shade |
| 286 | King Baby | Neutral | Hard | Defeat Delirium as ??? | 320 | https://bindingofisaacrebirth.wiki.gg//wiki/King_Baby |
| 287 | Bloody Crown | Good | Average difficulty | Defeat Delirium as Samson | 67, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Bloody_Crown |
| 288 | Dull Razor | Bad | Average difficulty | Defeat Delirium as Eve | 79, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Dull_Razor |
| 289 | Eden's Soul | Good | Average difficulty | Defeat Delirium as Eden | 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Eden%27s_Soul |
| 290 | Dark Prince's Crown | Neutral | Average difficulty | Defeat Delirium as Azazel | 79, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Dark_Prince%27s_Crown |
| 291 | Compound Fracture | Good | Average difficulty | Defeat Delirium as Lazarus | 80, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Compound_Fracture |
| 292 | Euthanasia | Great | Average difficulty | Defeat Delirium as Lilith | 199, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Euthanasia |
| 293 | Holy Card | Good | Insanely hard | Defeat Delirium as The Lost | 82, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Holy_Card |
| 294 | Crooked Penny | Good | Insanely hard | Defeat Delirium as Keeper | 251, 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Crooked_Penny |
| 295 | Void | Good | Average difficulty | Defeat Delirium as Apollyon | 320, 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Void |
| 296 | D1 | Good | Average difficulty | Defeat Ultra Greedier as Isaac | 192, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/D1 |
| 297 | Glyph of Balance | Good | Average difficulty | Defeat Ultra Greedier as Magdalene | 193, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Glyph_of_Balance |
| 298 | Sack of Sacks | Good | Average difficulty | Defeat Ultra Greedier as Cain | 194, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Sack_of_Sacks |
| 299 | Eye of Belial | Great | Average difficulty | Defeat Ultra Greedier as Judas | 195, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Eye_of_Belial |
| 300 | Meconium | Neutral | Hard | Defeat Ultra Greedier as ??? | 196, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Meconium |
| 301 | Stem Cell | Good | Average difficulty | Defeat Ultra Greedier as Samson | 198, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Stem_Cell |
| 302 | Crow Heart | Good | Average difficulty | Defeat Ultra Greedier as Eve | 197, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Crow_Heart |
| 303 | Metronome | Bad | Average difficulty | Defeat Ultra Greedier as Eden | 201, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Metronome |
| 304 | Bat Wing | Neutral | Average difficulty | Defeat Ultra Greedier as Azazel | 199, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Bat_Wing |
| 305 | Plan C | Bad | Average difficulty | Defeat Ultra Greedier as Lazarus | 200, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Plan_C |
| 306 | Duality | Good | Average difficulty | Defeat Ultra Greedier as Lilith | 203, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Duality |
| 307 | Dad's Lost Coin | Bad | Hard | Defeat Ultra Greedier as The Lost | 202, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Dad%27s_Lost_Coin |
| 308 | Eye of Greed | Good | Hard | Defeat Ultra Greedier as Keeper | 204 | https://bindingofisaacrebirth.wiki.gg//wiki/Eye_of_Greed |
| 309 | Black Rune | Good | Average difficulty | Defeat Ultra Greedier as Apollyon | 316, 341 | https://bindingofisaacrebirth.wiki.gg//wiki/Black_Rune |
| 310 | Locust of Wrath | Good | Average difficulty | Defeat Isaac as Apollyon | 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Locust_of_War |
| 311 | Locust of Pestilence | Good | Average difficulty | Defeat Satan as Apollyon | 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Locust_of_Pestilence |
| 312 | Locust of Famine | Good | Average difficulty | Defeat ??? as Apollyon | 57, 310 | https://bindingofisaacrebirth.wiki.gg//wiki/Locust_of_Famine |
| 313 | Locust of Death | Good | Average difficulty | Defeat The Lamb as Apollyon | 78, 311 | https://bindingofisaacrebirth.wiki.gg//wiki/Locust_of_Death |
| 314 | Locust of Conquest | Good | Average difficulty | Complete the Boss Rush as Apollyon | 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Locust_of_Conquest |
| 315 | Hushy | Neutral | Average difficulty | Defeat Hush as Apollyon | 234, 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Hushy |
| 316 | Brown Nugget | Bad | Average difficulty | Defeat Ultra Greed as Apollyon | 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Brown_Nugget |
| 317 | Mort Baby | Neutral | Average difficulty | Defeat Mega Satan as Apollyon | 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 318 | Smelter | Good | Average difficulty | Defeat Mom's Heart or It Lives! on Hard mode as Apollyon | 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Smelter |
| 319 | Apollyon Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Apollyon | 295, 309, 312, 313, 314, 315, 317, 318, 466, 467 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 320 | New Area | Neutral | Average difficulty | Defeat Hush | 234 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Void |
| 321 | Once More with Feeling! | Good | Easy | Complete a Victory Lap by defeating The Lamb | 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Gulp! |
| 322 | Hat trick! | Great | Average difficulty | Get a 3-win streak | 4 | https://bindingofisaacrebirth.wiki.gg//wiki/Ace_of_Clubs |
| 323 | 5 Nights at Mom's | Good | Average difficulty | Get a 5-win streak, using a different character each time (can be reduced to 3, check wiki for more info) | 322 | https://bindingofisaacrebirth.wiki.gg//wiki/Super_special_rock |
| 324 | Sin collector | Neutral | Hard | Collect every entry in the Bestiary (bugged, check wiki for more info) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Feels_Like_I%27m_Walking_on_Sunshine! |
| 325 | Dedication | Terrible | Easy | Participate in 31 Daily Challenges (not need to be successful or consecutive) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Horf! |
| 326 | ZIP! | Great | Insanely hard | Defeat The Lamb in under 20 minutes | 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Ace_of_Diamonds |
| 327 | It's the Key | Great | Hard | Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run. Letting certain familiars or bosses pick up the consumables fails this condition as well. | 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Ace_of_Spades_(Card) |
| 328 | Mr. Resetter! | Terrible | Easy | Reset 7 times in a row | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Hearts#Scared_Heart |
| 329 | Living on the edge | Great | Average difficulty | Complete a Chapter after Basement, start-to-finish, with only half a Heart total | 13 | https://bindingofisaacrebirth.wiki.gg//wiki/Ace_of_Hearts |
| 330 | U Broke It! | Good | Hard | Obtain 50 items in a run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Vurp! |
| 331 | Laz Bleeds More! | Great | Average difficulty | Complete Backasswards (challenge #31) | 277 | https://bindingofisaacrebirth.wiki.gg//wiki/Lazarus |
| 332 | Maggy Now Holds a Pill! | Great | Hard | Complete Aprils Fool (challenge #32) | 278 | https://bindingofisaacrebirth.wiki.gg//wiki/Magdalene |
| 333 | Charged Key | Epic | Average difficulty | Complete Pokey Mans (challenge #33) | 279 | https://bindingofisaacrebirth.wiki.gg//wiki/Charged_Key |
| 334 | Samson Feels Healthy! | Good | Insanely hard | Complete Ultra Hard (challenge #34) | 280 | https://bindingofisaacrebirth.wiki.gg//wiki/Samson |
| 335 | Greed's Gullet | Neutral | Easy | Complete Pong (challenge #35) | 281 | https://bindingofisaacrebirth.wiki.gg//wiki/Greed%27s_Gullet |
| 336 | The Marathon | Good | Hard | Get a 5-win streak in the Daily Challenges (not need to be consecutive days) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Cracked_Crown |
| 337 | RERUN | Neutral | Average difficulty | Complete 3 Victory Laps by defeating The Lamb | 360 | https://bindingofisaacrebirth.wiki.gg//wiki/RERUN |
| 338 | Delirious | Good | Average difficulty | Defeat Delirium | 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Delirious |
| 339 | 1000000% | Neutral | Hard | Unlocked after reaching a certain point of completion of secrets, endings and Bestiary | 84, 324 | https://bindingofisaacrebirth.wiki.gg/# |
| 340 | Apollyon | Good | Average difficulty | Defeat Mega Satan | 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Apollyon |
| 341 | Greedier! | Neutral | Average difficulty | Donate 500 Coins to the Greed Donation Machine | 248 | https://bindingofisaacrebirth.wiki.gg//wiki/Greedier_Mode |
| 342 | Burning Basement | Neutral | Average difficulty | Defeat Mom's Heart 11 times | 34 | https://bindingofisaacrebirth.wiki.gg//wiki/Burning_Basement |
| 343 | Flooded Caves | Neutral | Average difficulty | Defeat It Lives! 16 times | 342 | https://bindingofisaacrebirth.wiki.gg//wiki/Flooded_Caves |
| 344 | Dank Depths | Neutral | Average difficulty | Defeat It Lives! 21 times | 343 | https://bindingofisaacrebirth.wiki.gg//wiki/Dank_Depths |
| 345 | Scarred Womb | Neutral | Average difficulty | Defeat It Lives! 30 times | 344 | https://bindingofisaacrebirth.wiki.gg//wiki/Scarred_Womb |
| 346 | Something wicked this way comes! | Neutral | Average difficulty | Defeat ??? as 3 different Characters | 57 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Binding_of_Isaac:_Afterbirth#Bosses |
| 347 | Something wicked this way comes+! | Neutral | Average difficulty | Defeat ??? as 6 different Characters | 346 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Binding_of_Isaac:_Afterbirth_%E2%80%A0#Bosses |
| 348 | The gate is open! | Bad | Average difficulty | Defeat The Lamb | 78 | https://bindingofisaacrebirth.wiki.gg//wiki/Portal |
| 349 | Black Hole | Neutral | Average difficulty | Defeat 20 Portals | 348 | https://bindingofisaacrebirth.wiki.gg//wiki/Black_Hole |
| 350 | Mystery Gift | Good | Easy | Destroy 500 rocks | 85 | https://bindingofisaacrebirth.wiki.gg//wiki/Mystery_Gift |
| 351 | Sprinkler | Bad | Automatic | Beat Chapter 1 without taking damage | 37 | https://bindingofisaacrebirth.wiki.gg//wiki/Sprinkler |
| 352 | Angry Fly | Bad | Automatic | Become Beelzebub | 178 | https://bindingofisaacrebirth.wiki.gg//wiki/Angry_Fly |
| 353 | Bozo | Good | Easy | Destroy 5 rainbow poops | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Bozo |
| 354 | Broken Modem | Good | Average difficulty | Complete 7 Daily Challenges (by touching the trophy at the end) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Broken_Modem |
| 355 | Buddy in a Box | Neutral | Average difficulty | Pick up 5 familiars in a single run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Buddy_in_a_Box |
| 356 | Fast Bombs | Good | Average difficulty | Defeat Little Horn 20 times | 346 | https://bindingofisaacrebirth.wiki.gg//wiki/Fast_Bombs |
| 357 | Lil Delirium | Neutral | Automatic | Defeat Delirium | 338 | https://bindingofisaacrebirth.wiki.gg//wiki/Lil_Delirium |
| 358 | Hairpin | Good | Easy | Recharge using Lil' Batteries 20 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Hairpin |
| 359 | Wooden Cross | Great | Easy | Sleep in a bed | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Wooden_Cross |
| 360 | Butter! | Bad | Easy | Complete 2 Victory Laps by defeating The Lamb | 321 | https://bindingofisaacrebirth.wiki.gg//wiki/Butter! |
| 361 | Huge Growth | Good | Hard | Increase in size 5 times in a single run via Magic Mushroom, "One makes you larger" pills, XI - Strength, etc. | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Huge_Growth |
| 362 | Ancient Recall | Good | Easy | Use Cards and Runes 20 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Ancient_Recall |
| 363 | Era Walk | Great | Easy | Add both the Broken Watch and the Stop Watch to your collection | 138 | https://bindingofisaacrebirth.wiki.gg//wiki/Era_Walk |
| 364 | Coupon | Good | Easy | Purchase anything from Shops, Devil Rooms, and/or Black Markets 50 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Coupon |
| 365 | Telekinesis | Neutral | Automatic | Beat Chapter 2 without taking damage | 38 | https://bindingofisaacrebirth.wiki.gg//wiki/Telekinesis |
| 366 | Moving Box | Bad | Average difficulty | Use Pandora's Box in Dark Room | 119 | https://bindingofisaacrebirth.wiki.gg//wiki/Moving_Box |
| 367 | Jumper Cables | Good | Easy | Pick up any 2 items that have the 'battery' item tag in a single run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Jumper_Cables |
| 368 | Leprosy | Bad | Automatic | Beat Chapter 3 without taking damage | 39 | https://bindingofisaacrebirth.wiki.gg//wiki/Leprosy |
| 369 | Technology Zero | Good | Easy | Pick up any 2 items that have the 'tech' item tag in a single run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Technology_Zero |
| 370 | Filigree Feather | Great | Easy | Acquire both Key Piece 1 and Key Piece 2 | 155 | https://bindingofisaacrebirth.wiki.gg//wiki/Filigree_Feather |
| 371 | Mr. ME! | Good | Easy | Open 20 Locked Chests | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Mr._ME! |
| 372 | 7 Seals | Good | Easy | Defeat all 5 Harbingers | 7 | https://bindingofisaacrebirth.wiki.gg//wiki/7_Seals |
| 373 | Angelic Prism | Good | Easy | Defeat an Angel 10 times | 155 | https://bindingofisaacrebirth.wiki.gg//wiki/Angelic_Prism |
| 374 | Pop! | Good | Automatic | Beat Chapter 4 without taking damage | 40 | https://bindingofisaacrebirth.wiki.gg//wiki/Pop! |
| 375 | Door Stop | Great | Easy | Blow up doors and Secret Room walls 50 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Door_Stop |
| 376 | Death's List | Bad | Easy | Take 25 Deals with the Devil | 79 | https://bindingofisaacrebirth.wiki.gg//wiki/Death%27s_List |
| 377 | Haemolacria | Great | Easy | Acquire Blood Clot 10 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Haemolacria |
| 378 | Lachryphagy | Good | Easy | Collect 10 "Tears Up" items or pills in one run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Lachryphagy |
| 379 | Schoolbag | Great | Easy | Enter 6 Shops in one run | 14 | https://bindingofisaacrebirth.wiki.gg//wiki/Schoolbag |
| 380 | Trisagion | Great | Easy | Take 25 Angel Rooms items | 66 | https://bindingofisaacrebirth.wiki.gg//wiki/Trisagion |
| 381 | Extension Cord | Good | Easy | Have The Battery, 9 Volt, and Car Battery in Isaac's collection | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Extension_Cord |
| 382 | Flat Stone | Neutral | Easy | Acquire Rubber Cement 5 times | 150 | https://bindingofisaacrebirth.wiki.gg//wiki/Flat_Stone |
| 383 | Sacrificial Altar | Good | Easy | Take 50 Deals with the Devil | 376 | https://bindingofisaacrebirth.wiki.gg//wiki/Sacrificial_Altar |
| 384 | Lil Spewer | Neutral | Easy | Have Isaac die to his own explosion from Ipecac, Bob's Rotten Head, or a Horf! pill | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Lil_Spewer |
| 385 | Blanket | Great | Easy | Sleep in 10 beds | 359 | https://bindingofisaacrebirth.wiki.gg//wiki/Blanket |
| 386 | Marbles | Good | Easy | Use 5 Gulp! pills in one run (Placebo uses count) | 321 | https://bindingofisaacrebirth.wiki.gg//wiki/Marbles |
| 387 | Mystery Egg | Bad | Easy | Spawn three charmed enemies in the same room | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Mystery_Egg |
| 388 | Rotten Penny | Great | Easy | Have 20 Blue Flies at the same time | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Rotten_Penny |
| 389 | Baby-Bender | Good | Easy | Use I - The Magician or Telepathy For Dummies while already having homing tears | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Baby-Bender |
| 390 | The Forgotten | Great | Hard | It's complicated | 348 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Forgotten#Unlocking_the_Forgotten |
| 391 | Bone Heart | Great | Automatic | It's complicated | 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Hearts_(Pickup) |
| 392 | Marrow | Neutral | Average difficulty | Defeat Mom's Heart or It Lives! on Hard mode as The Forgotten | 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Marrow |
| 393 | Slipped Rib | Good | Average difficulty | Defeat Isaac as The Forgotten | 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Slipped_Rib |
| 394 | Pointy Rib | Good | Average difficulty | Defeat Satan as The Forgotten | 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Pointy_Rib |
| 395 | Jaw Bone | Neutral | Average difficulty | Defeat ??? as The Forgotten | 57, 393 | https://bindingofisaacrebirth.wiki.gg//wiki/Jaw_Bone |
| 396 | Brittle Bones | Good | Average difficulty | Defeat The Lamb as The Forgotten | 394 | https://bindingofisaacrebirth.wiki.gg//wiki/Brittle_Bones |
| 397 | Divorce Papers | Good | Average difficulty | Complete the Boss Rush as The Forgotten | 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Divorce_Papers |
| 398 | Hallowed Ground | Bad | Hard | Defeat Hush as The Forgotten | 234, 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Hallowed_Ground |
| 399 | Finger Bone | Good | Average difficulty | Defeat Ultra Greed as The Forgotten | 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Finger_Bone |
| 400 | Dad's Ring | Good | Hard | Defeat Ultra Greedier as The Forgotten | 341, 399 | https://bindingofisaacrebirth.wiki.gg//wiki/Dad%27s_Ring |
| 401 | Book of the Dead | Neutral | Hard | Defeat Delirium as The Forgotten | 320, 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Book_of_the_Dead |
| 402 | Bone Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as The Forgotten | 392, 395, 396, 397, 398, 400, 401, 403, 468, 469 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 403 | Bound Baby | Neutral | Average difficulty | Defeat Mega Satan as The Forgotten | 58, 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Babies |
| 404 | Bethany | Good | Average difficulty | Defeat Mom's Heart/It Lives! on hard mode as Lazarus, without dying at all | 4, 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Bethany |
| 405 | Jacob and Esau | Good | Average difficulty | Defeat Mother | 411 | https://bindingofisaacrebirth.wiki.gg//wiki/Jacob_and_Esau |
| 406 | The Planetarium | Epic | Hard | Collect any 3 items with the 'stars' item tag in a single run | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Planetarium |
| 407 | A Secret Exit | Epic | Average difficulty | Defeat Hush 3 times | 320 | https://bindingofisaacrebirth.wiki.gg//wiki/Downpour |
| 408 | Forgotten Lullaby | Good | Average difficulty | Blow up The Siren's skull after defeating her | 407 | https://bindingofisaacrebirth.wiki.gg//wiki/Forgotten_Lullaby |
| 409 | Fruity Plum | Neutral | Average difficulty | Defeat Baby Plum 10 times | 347 | https://bindingofisaacrebirth.wiki.gg//wiki/Fruity_Plum |
| 410 | Plum Flute | Neutral | Easy | Allow Baby Plum to escape instead of defeating her | 347 | https://bindingofisaacrebirth.wiki.gg//wiki/Plum_Flute |
| 411 | Rotten Heart | Epic | Average difficulty | Enter Corpse for the first time | 407 | https://bindingofisaacrebirth.wiki.gg//wiki/Rotten_Heart |
| 412 | Dross | Neutral | Average difficulty | Defeat all bosses in Downpour | 407 | https://bindingofisaacrebirth.wiki.gg//wiki/Dross |
| 413 | Ashpit | Neutral | Average difficulty | Defeat all bosses in Mines | 407 | https://bindingofisaacrebirth.wiki.gg//wiki/Ashpit |
| 414 | Gehenna | Neutral | Average difficulty | Defeat all bosses in Mausoleum | 407 | https://bindingofisaacrebirth.wiki.gg//wiki/Gehenna |
| 415 | Red Key | Great | Average difficulty | Open Mom's Chest in Home | 635 | https://bindingofisaacrebirth.wiki.gg//wiki/Red_Key |
| 416 | Wisp Baby | Neutral | Average difficulty | Defeat Mom's Heart or It Lives! on Hard mode as Bethany | 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Co-op#Repentance_babies |
| 417 | Book of Virtues | Great | Average difficulty | Defeat Isaac as Bethany | 81, 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Book_of_Virtues |
| 418 | Urn of Souls | Good | Average difficulty | Defeat Satan as Bethany | 81, 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Urn_of_Souls |
| 419 | Blessed Penny | Great | Average difficulty | Defeat ??? as Bethany | 57, 417 | https://bindingofisaacrebirth.wiki.gg//wiki/Blessed_Penny |
| 420 | Alabaster Box | Good | Average difficulty | Defeat The Lamb as Bethany | 78, 418 | https://bindingofisaacrebirth.wiki.gg//wiki/Alabaster_Box |
| 421 | Beth's Faith | Good | Average difficulty | Complete the Boss Rush as Bethany | 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Beth%27s_Faith |
| 422 | Soul Locket | Good | Average difficulty | Defeat Ultra Greed as Bethany | 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_Locket |
| 423 | Divine Intervention | Good | Average difficulty | Defeat Hush as Bethany | 234, 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Divine_Intervention |
| 424 | Vade Retro | Good | Average difficulty | Defeat Ultra Greedier as Bethany | 341, 422 | https://bindingofisaacrebirth.wiki.gg//wiki/Vade_Retro |
| 425 | Star of Bethlehem | Good | Average difficulty | Defeat Delirium as Bethany | 320, 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Star_of_Bethlehem |
| 426 | Hope Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Bethany | 416, 419, 420, 421, 423, 424, 425, 427, 470, 471 | https://bindingofisaacrebirth.wiki.gg//wiki/Co-op#Repentance_babies |
| 427 | Glowing Baby | Neutral | Average difficulty | Defeat Mega Satan as Bethany | 58, 404 | https://bindingofisaacrebirth.wiki.gg//wiki/Co-op#Repentance_babies |
| 428 | Double Baby | Neutral | Average difficulty | Defeat Mom's Heart or It Lives! on Hard mode as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Co-op#Repentance_babies |
| 429 | The Stairway | Great | Average difficulty | Defeat Isaac as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Stairway |
| 430 | Red Stew | Good | Average difficulty | Defeat Satan as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Red_Stew |
| 431 | Birthright | Epic | Average difficulty | Defeat ??? as Jacob and Esau | 57, 429 | https://bindingofisaacrebirth.wiki.gg//wiki/Birthright |
| 432 | Damocles | Good | Average difficulty | Defeat The Lamb as Jacob and Esau | 78, 430 | https://bindingofisaacrebirth.wiki.gg//wiki/Damocles |
| 433 | Rock Bottom | Great | Average difficulty | Complete Boss Rush as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Rock_Bottom |
| 434 | Inner Child | Good | Average difficulty | Defeat Ultra Greed as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Inner_Child |
| 435 | Vanishing Twin | Good | Hard | Defeat Hush as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Vanishing_Twin |
| 436 | Genesis | Great | Hard | Defeat Ultra Greedier as Jacob and Esau | 341, 434 | https://bindingofisaacrebirth.wiki.gg//wiki/Genesis |
| 437 | Suplex! | Good | Hard | Defeat Delirium as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Suplex! |
| 438 | Solomon's Baby | Neutral | Automatic | Earn all Hard mode Completion Marks as Jacob and Esau | 428, 431, 432, 433, 435, 436, 437, 439, 472, 473 | https://bindingofisaacrebirth.wiki.gg//wiki/Co-op#Repentance_babies |
| 439 | Illusion Baby | Neutral | Average difficulty | Defeat Mega Satan as Jacob and Esau | 405, 58 | https://bindingofisaacrebirth.wiki.gg//wiki/Co-op#Repentance_babies |
| 440 | Meat Cleaver | Bad | Average difficulty | Defeat Mother as Isaac | 411 | https://bindingofisaacrebirth.wiki.gg//wiki/Meat_Cleaver |
| 441 | Options? | Good | Average difficulty | Defeat The Beast as Isaac | 635 | https://bindingofisaacrebirth.wiki.gg//wiki/Options%3F |
| 442 | Yuck Heart | Neutral | Average difficulty | Defeat Mother as Magdalene | 411, 1 | https://bindingofisaacrebirth.wiki.gg//wiki/Yuck_Heart |
| 443 | Candy Heart | Good | Average difficulty | Defeat The Beast as Magdalene | 635, 1 | https://bindingofisaacrebirth.wiki.gg//wiki/Candy_Heart |
| 444 | Guppy's Eye | Great | Average difficulty | Defeat Mother as Cain | 411, 2 | https://bindingofisaacrebirth.wiki.gg//wiki/Guppy%27s_Eye |
| 445 | A Pound of Flesh | Neutral | Average difficulty | Defeat The Beast as Cain | 635, 2 | https://bindingofisaacrebirth.wiki.gg//wiki/A_Pound_of_Flesh |
| 446 | Akeldama | Neutral | Average difficulty | Defeat Mother as Judas | 411, 3 | https://bindingofisaacrebirth.wiki.gg//wiki/Akeldama |
| 447 | Redemption | Good | Average difficulty | Defeat The Beast as Judas | 635, 3 | https://bindingofisaacrebirth.wiki.gg//wiki/Redemption |
| 448 | Eternal D6 | Epic | Hard | Defeat Mother as ??? | 411 | https://bindingofisaacrebirth.wiki.gg//wiki/Eternal_D6 |
| 449 | Montezuma's Revenge | Bad | Average difficulty | Defeat The Beast as ??? | 635 | https://bindingofisaacrebirth.wiki.gg//wiki/Montezuma%27s_Revenge |
| 450 | Bird Cage | Neutral | Hard | Defeat Mother as Eve | 411, 42 | https://bindingofisaacrebirth.wiki.gg//wiki/Bird_Cage |
| 451 | Cracked Orb | Neutral | Average difficulty | Defeat The Beast as Eve | 635, 42 | https://bindingofisaacrebirth.wiki.gg//wiki/Cracked_Orb |
| 452 | Bloody Gust | Good | Average difficulty | Defeat Mother as Samson | 411, 67 | https://bindingofisaacrebirth.wiki.gg//wiki/Bloody_Gust |
| 453 | Empty Heart | Neutral | Average difficulty | Defeat The Beast as Samson | 635, 67 | https://bindingofisaacrebirth.wiki.gg//wiki/Empty_Heart |
| 454 | Devil's Crown | Good | Average difficulty | Defeat Mother as Azazel | 411, 79 | https://bindingofisaacrebirth.wiki.gg//wiki/Devil%27s_Crown |
| 455 | Lil Abaddon | Good | Average difficulty | Defeat The Beast as Azazel | 635, 79 | https://bindingofisaacrebirth.wiki.gg//wiki/Lil_Abaddon |
| 456 | Tinytoma | Neutral | Hard | Defeat Mother as Lazarus | 411, 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Tinytoma |
| 457 | Astral Projection | Neutral | Average difficulty | Defeat The Beast as Lazarus | 635, 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Astral_Projection |
| 458 | 'M | Good | Average difficulty | Defeat Mother as Eden | 411 | https://bindingofisaacrebirth.wiki.gg//wiki/%27M |
| 459 | Everything Jar | Neutral | Average difficulty | Defeat The Beast as Eden | 635 | https://bindingofisaacrebirth.wiki.gg//wiki/Everything_Jar |
| 460 | Lost Soul | Good | Insanely hard | Defeat Mother as The Lost | 411, 82 | https://bindingofisaacrebirth.wiki.gg//wiki/Lost_Soul |
| 461 | Hungry Soul | Good | Hard | Defeat The Beast as The Lost | 635, 82 | https://bindingofisaacrebirth.wiki.gg//wiki/Hungry_Soul |
| 462 | Blood Puppy | Neutral | Hard | Defeat Mother as Lilith | 411, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Blood_Puppy |
| 463 | C Section | Epic | Average difficulty | Defeat The Beast as Lilith | 635, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/C_Section |
| 464 | Keeper's Sack | Good | Hard | Defeat Mother as Keeper | 411, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper%27s_Sack |
| 465 | Keeper's Box | Neutral | Hard | Defeat The Beast as Keeper | 635, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper%27s_Box |
| 466 | Lil Portal | Good | Average difficulty | Defeat Mother as Apollyon | 411, 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Lil_Portal |
| 467 | Worm Friend | Good | Average difficulty | Defeat The Beast as Apollyon | 635, 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Worm_Friend |
| 468 | Bone Spurs | Good | Hard | Defeat Mother as The Forgotten | 411, 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Bone_Spurs |
| 469 | Spirit Shackles | Neutral | Average difficulty | Defeat The Beast as The Forgotten | 635, 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Spirit_Shackles |
| 470 | Revelation | Epic | Average difficulty | Defeat Mother as Bethany | 404, 411 | https://bindingofisaacrebirth.wiki.gg//wiki/Revelation |
| 471 | Jar of Wisps | Good | Average difficulty | Defeat The Beast as Bethany | 404, 635 | https://bindingofisaacrebirth.wiki.gg//wiki/Jar_of_Wisps |
| 472 | Magic Skin | Great | Hard | Defeat Mother as Jacob and Esau | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Magic_Skin |
| 473 | Friend Finder | Bad | Hard | Defeat The Beast as Jacob and Esau | 635 | https://bindingofisaacrebirth.wiki.gg//wiki/Friend_Finder |
| 474 | The Broken | Great | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Isaac | 415 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Isaac |
| 475 | The Dauntless | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Magdalene | 415, 1 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Magdalene |
| 476 | The Hoarder | Great | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Cain | 415, 2 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Cain |
| 477 | The Deceiver | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Judas | 415, 3 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Judas |
| 478 | The Soiled | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as ??? | 415 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_%3F%3F%3F |
| 479 | The Curdled | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Eve | 415, 42 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Eve |
| 480 | The Savage | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Samson | 415, 67 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Samson |
| 481 | The Benighted | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Azazel | 415, 79 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Azazel |
| 482 | The Enigma | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Lazarus | 415, 80 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Lazarus |
| 483 | The Capricious | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Eden | 415 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Eden |
| 484 | The Baleful | Good | Hard | Use Red Key (etc.) to open the hidden closet in Home as The Lost | 415, 82 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Lost |
| 485 | The Harlot | Great | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Lilith | 415, 199 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Lilith |
| 486 | The Miser | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Keeper | 415, 251 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Keeper |
| 487 | The Empty | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Apollyon | 415, 340 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Apollyon |
| 488 | The Fettered | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as The Forgotten | 415, 390 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Forgotten |
| 489 | The Zealot | Great | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Bethany | 404, 415 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Bethany |
| 490 | The Deserter | Good | Average difficulty | Use Red Key (etc.) to open the hidden closet in Home as Jacob and Esau | 415 | https://bindingofisaacrebirth.wiki.gg//wiki/Tainted_Jacob |
| 491 | Glitched Crown | Epic | Average difficulty | Defeat The Beast as Tainted Isaac | 474 | https://bindingofisaacrebirth.wiki.gg//wiki/Glitched_Crown |
| 492 | Belly Jelly | Good | Average difficulty | Defeat The Beast as Tainted Magdalene | 475 | https://bindingofisaacrebirth.wiki.gg//wiki/Belly_Jelly |
| 493 | Blue Key | Good | Average difficulty | Defeat The Beast as Tainted Cain | 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Blue_Key |
| 494 | Sanguine Bond | Bad | Average difficulty | Defeat The Beast as Tainted Judas | 477 | https://bindingofisaacrebirth.wiki.gg//wiki/Sanguine_Bond |
| 495 | The Swarm | Good | Average difficulty | Defeat The Beast as Tainted ??? | 478 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Swarm |
| 496 | Heartbreak | Good | Average difficulty | Defeat The Beast as Tainted Eve | 479 | https://bindingofisaacrebirth.wiki.gg//wiki/Heartbreak |
| 497 | Larynx | Good | Average difficulty | Defeat The Beast as Tainted Samson | 480 | https://bindingofisaacrebirth.wiki.gg//wiki/Larynx |
| 498 | Azazel's Rage | Good | Average difficulty | Defeat The Beast as Tainted Azazel | 481 | https://bindingofisaacrebirth.wiki.gg//wiki/Azazel%27s_Rage |
| 499 | Salvation | Good | Average difficulty | Defeat The Beast as Tainted Lazarus | 482 | https://bindingofisaacrebirth.wiki.gg//wiki/Salvation |
| 500 | TMTRAINER | Neutral | Hard | Defeat The Beast as Tainted Eden | 483 | https://bindingofisaacrebirth.wiki.gg//wiki/TMTRAINER |
| 501 | Sacred Orb | Epic | Hard | Defeat The Beast as Tainted Lost | 484 | https://bindingofisaacrebirth.wiki.gg//wiki/Sacred_Orb |
| 502 | Twisted Pair | Epic | Average difficulty | Defeat The Beast as Tainted Lilith | 485 | https://bindingofisaacrebirth.wiki.gg//wiki/Twisted_Pair |
| 503 | Strawman | Bad | Hard | Defeat The Beast as Tainted Keeper | 486 | https://bindingofisaacrebirth.wiki.gg//wiki/Strawman |
| 504 | Echo Chamber | Great | Average difficulty | Defeat The Beast as Tainted Apollyon | 487 | https://bindingofisaacrebirth.wiki.gg//wiki/Echo_Chamber |
| 505 | Isaac's Tomb | Good | Average difficulty | Defeat The Beast as Tainted Forgotten | 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Isaac%27s_Tomb |
| 506 | Vengeful Spirit | Neutral | Average difficulty | Defeat The Beast as Tainted Bethany | 489 | https://bindingofisaacrebirth.wiki.gg//wiki/Vengeful_Spirit |
| 507 | Esau Jr. | Neutral | Hard | Defeat The Beast as Tainted Jacob | 490 | https://bindingofisaacrebirth.wiki.gg//wiki/Esau_Jr. |
| 508 | Bloody Mary | Neutral | Automatic | Unlock Bethany, Blood Bag, and It Lives! | 34, 404, 147 | https://bindingofisaacrebirth.wiki.gg//wiki/Bloody_Mary |
| 509 | Baptism by Fire | Neutral | Automatic | Defeat Satan as Bethany, defeat Mom's Heart 11 times, and unlock Maggy's Faith | 34, 71, 418 | https://bindingofisaacrebirth.wiki.gg//wiki/Baptism_by_Fire |
| 510 | Isaac's Awakening | Neutral | Automatic | Defeat Mother | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Isaac%27s_Awakening |
| 511 | Seeing Double | Neutral | Automatic | Defeat Mother | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/Seeing_Double |
| 512 | Pica Run | Neutral | Automatic | Defeat Mom's Heart 11 times and unlock Marbles | 34, 386 | https://bindingofisaacrebirth.wiki.gg//wiki/Pica_Run |
| 513 | Hot Potato | Neutral | Automatic | Unlock Tainted Forgotten | 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Hot_Potato |
| 514 | Cantripped! | Neutral | Automatic | Unlock Tainted Cain | 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Cantripped! |
| 515 | Red Redemption | Neutral | Automatic | Unlock Tainted Jacob | 490 | https://bindingofisaacrebirth.wiki.gg//wiki/Red_Redemption |
| 516 | DELETE THIS | Neutral | Automatic | Unlock Tainted Eden | 483 | https://bindingofisaacrebirth.wiki.gg//wiki/DELETE_THIS |
| 517 | Dirty Mind | Neutral | Average difficulty | Complete Scat Man (challenge #36) | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Dirty_Mind |
| 518 | Sigil of Baphomet | Epic | Hard | Complete Bloody Mary (challenge #37) | 508 | https://bindingofisaacrebirth.wiki.gg//wiki/Sigil_of_Baphomet |
| 519 | Purgatory | Bad | Hard | Complete Baptism by Fire (challenge #38) | 509 | https://bindingofisaacrebirth.wiki.gg//wiki/Purgatory |
| 520 | Spirit Sword | Great | Hard | Complete Isaac's Awakening (challenge #39) | 510 | https://bindingofisaacrebirth.wiki.gg//wiki/Spirit_Sword |
| 521 | Broken Glasses | Great | Average difficulty | Complete Seeing Double (challenge #40) | 511 | https://bindingofisaacrebirth.wiki.gg//wiki/Broken_Glasses |
| 522 | Ice Cube | Good | Hard | Complete Pica Run (challenge #41) | 512 | https://bindingofisaacrebirth.wiki.gg//wiki/Ice_Cube |
| 523 | Charged Penny | Good | Easy | Donate to Battery Bums until they pay out with an item 5 times | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Charged_Penny |
| 524 | The Fool | Neutral | Insanely hard | Defeat Ultra Greedier as Tainted Lost | 341, 484 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 525 | The Magician | Good | Average difficulty | Defeat Ultra Greedier as Tainted Judas | 341, 477 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 526 | The High Priestess | Terrible | Average difficulty | Defeat Ultra Greedier as Tainted Lilith | 341, 485 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 527 | The Empress | Good | Average difficulty | Defeat Ultra Greedier as Tainted Eve | 341, 479 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 528 | The Emperor | Good | Average difficulty | Defeat Ultra Greedier as Tainted ??? | 341, 478 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 529 | The Hierophant | Good | Average difficulty | Defeat Ultra Greedier as Tainted Bethany | 341, 489 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 530 | The Lovers | Good | Average difficulty | Defeat Ultra Greedier as Tainted Magdalene | 341, 475 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 531 | The Chariot | Good | Insanely hard | Complete Hot Potato (challenge #42) | 513 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 532 | Justice | Good | Easy | Complete Cantripped (challenge #43) | 514 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 533 | The Hermit | Neutral | Hard | Complete Red Redemption (challenge #44) | 515 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 534 | Wheel of Fortune | Bad | Average difficulty | Defeat Ultra Greedier as Tainted Cain | 341, 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 535 | Strength | Good | Average difficulty | Defeat Ultra Greedier as Tainted Samson | 341, 480 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 536 | The Hanged Man | Good | Hard | Defeat Ultra Greedier as Tainted Keeper | 486 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 537 | Death | Bad | Hard | Defeat Ultra Greedier as Tainted Forgotten | 341, 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 538 | Temperance | Neutral | Average difficulty | Complete DELETE THIS (challenge #45) | 516 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 539 | The Devil | Neutral | Average difficulty | Defeat Ultra Greedier as Tainted Azazel | 341, 481 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 540 | The Tower | Bad | Average difficulty | Defeat Ultra Greedier as Tainted Apollyon | 341, 487 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 541 | The Stars | Great | Average difficulty | Defeat Ultra Greedier as Tainted Isaac | 341, 474 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 542 | The Sun and the Moon | Great | Hard | Defeat Ultra Greedier as Tainted Jacob | 341, 490 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 543 | Judgement | Epic | Hard | Defeat Ultra Greedier as Tainted Lazarus | 341, 482 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 544 | The World | Great | Hard | Defeat Ultra Greedier as Tainted Eden | 341, 483 | https://bindingofisaacrebirth.wiki.gg//wiki/Reverse_tarot_cards |
| 545 | Old Capacitor | Good | Easy | Kill 10 Battery Bums | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Old_Capacitor |
| 546 | Brimstone Bombs | Good | Average difficulty | After breaking Hornfel's minecart, kill him before he can escape | 407 | https://bindingofisaacrebirth.wiki.gg//wiki/Brimstone_Bombs |
| 547 | Mega Mush | Epic | Easy | Earn all Hard mode Completion Marks for all non-Tainted characters | 156, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 264, 319, 402, 426, 438 | https://bindingofisaacrebirth.wiki.gg//wiki/Mega_Mush |
| 548 | Mom's Lock | Bad | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Isaac | 41, 474 | https://bindingofisaacrebirth.wiki.gg//wiki/Mom%27s_Lock |
| 549 | Dice Bag | Great | Average difficulty | Defeat Mother as Tainted Isaac | 474 | https://bindingofisaacrebirth.wiki.gg//wiki/Dice_Bag |
| 550 | Holy Crown | Good | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Magdalene | 41, 475 | https://bindingofisaacrebirth.wiki.gg//wiki/Holy_Crown |
| 551 | Mother's Kiss | Good | Hard | Defeat Mother as Tainted Magdalene | 475 | https://bindingofisaacrebirth.wiki.gg//wiki/Mother%27s_Kiss |
| 552 | Gilded Key | Good | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Cain | 41, 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Gilded_Key |
| 553 | Lucky Sack | Good | Average difficulty | Defeat Mother as Tainted Cain | 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Lucky_Sack |
| 554 | Your Soul | Good | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Judas | 41, 477 | https://bindingofisaacrebirth.wiki.gg//wiki/Your_Soul |
| 555 | Number Magnet | Good | Average difficulty | Defeat Mother as Tainted Judas | 477 | https://bindingofisaacrebirth.wiki.gg//wiki/Number_Magnet |
| 556 | Dingle Berry | Neutral | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted ??? | 41, 478 | https://bindingofisaacrebirth.wiki.gg//wiki/Dingle_Berry |
| 557 | Ring Cap | Good | Hard | Defeat Mother as Tainted ??? | 478 | https://bindingofisaacrebirth.wiki.gg//wiki/Ring_Cap |
| 558 | Strange Key | Good | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Eve | 41, 479 | https://bindingofisaacrebirth.wiki.gg//wiki/Strange_Key |
| 559 | Lil Clot | Good | Average difficulty | Defeat Mother as Tainted Eve | 479 | https://bindingofisaacrebirth.wiki.gg//wiki/Lil_Clot |
| 560 | Temporary Tattoo | Good | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Samson | 41, 480 | https://bindingofisaacrebirth.wiki.gg//wiki/Temporary_Tattoo |
| 561 | Swallowed M80 | Neutral | Average difficulty | Defeat Mother as Tainted Samson | 480 | https://bindingofisaacrebirth.wiki.gg//wiki/Swallowed_M80 |
| 562 | Wicked Crown | Good | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Azazel | 41, 481 | https://bindingofisaacrebirth.wiki.gg//wiki/Wicked_Crown |
| 563 | Azazel's Stump | Neutral | Average difficulty | Defeat Mother as Tainted Azazel | 481 | https://bindingofisaacrebirth.wiki.gg//wiki/Azazel%27s_Stump |
| 564 | Torn Pocket | Bad | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Lazarus | 41, 482 | https://bindingofisaacrebirth.wiki.gg//wiki/Torn_Pocket |
| 565 | Torn Card | Terrible | Hard | Defeat Mother as Tainted Lazarus | 482 | https://bindingofisaacrebirth.wiki.gg//wiki/Torn_Card |
| 566 | Nuh Uh! | Good | Hard | Defeat Isaac, ???, Satan, and The Lamb as Tainted Eden | 41, 483 | https://bindingofisaacrebirth.wiki.gg//wiki/Nuh_Uh! |
| 567 | Modeling Clay | Good | Insanely hard | Defeat Mother as Tainted Eden | 483 | https://bindingofisaacrebirth.wiki.gg//wiki/Modeling_Clay |
| 568 | Kid's Drawing | Good | Hard | Defeat Isaac, ???, Satan, and The Lamb as Tainted Lost | 41, 484 | https://bindingofisaacrebirth.wiki.gg//wiki/Kid%27s_Drawing |
| 569 | Crystal Key | Good | Insanely hard | Defeat Mother as Tainted Lost | 484 | https://bindingofisaacrebirth.wiki.gg//wiki/Crystal_Key |
| 570 | The Twins | Neutral | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Lilith | 41, 485 | https://bindingofisaacrebirth.wiki.gg//wiki/The_Twins |
| 571 | Adoption Papers | Good | Average difficulty | Defeat Mother as Tainted Lilith | 485 | https://bindingofisaacrebirth.wiki.gg//wiki/Adoption_Papers |
| 572 | Keeper's Bargain | Good | Hard | Defeat Isaac, ???, Satan, and The Lamb as Tainted Keeper | 41, 486 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper%27s_Bargain |
| 573 | Cursed Penny | Terrible | Insanely hard | Defeat Mother as Tainted Keeper | 486 | https://bindingofisaacrebirth.wiki.gg//wiki/Cursed_Penny |
| 574 | Cricket Leg | Great | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Apollyon | 41, 487 | https://bindingofisaacrebirth.wiki.gg//wiki/Cricket_Leg |
| 575 | Apollyon's Best Friend | Good | Average difficulty | Defeat Mother as Tainted Apollyon | 487 | https://bindingofisaacrebirth.wiki.gg//wiki/Apollyon%27s_Best_Friend |
| 576 | Polished Bone | Neutral | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Forgotten | 41, 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Polished_Bone |
| 577 | Hollow Heart | Great | Hard | Defeat Mother as Tainted Forgotten | 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Hollow_Heart |
| 578 | Expansion Pack | Neutral | Average difficulty | Defeat Isaac, ???, Satan, and The Lamb as Tainted Bethany | 41, 489 | https://bindingofisaacrebirth.wiki.gg//wiki/Expansion_Pack |
| 579 | Beth's Essence | Neutral | Average difficulty | Defeat Mother as Tainted Bethany | 489 | https://bindingofisaacrebirth.wiki.gg//wiki/Beth%27s_Essence |
| 580 | RC Remote | Neutral | Hard | Defeat Isaac, ???, Satan, and The Lamb as Tainted Jacob | 41, 490 | https://bindingofisaacrebirth.wiki.gg//wiki/RC_Remote |
| 581 | Found Soul | Good | Insanely hard | Defeat Mother as Tainted Jacob | 490 | https://bindingofisaacrebirth.wiki.gg//wiki/Found_Soul |
| 582 | Member Card | Good | Easy | Spend 40+ coins in a single Shop | 0 | https://bindingofisaacrebirth.wiki.gg//wiki/Member_Card |
| 583 | Golden Razor | Bad | Easy | In a single run, obtain 99 Coins, then spend all of them | 2 | https://bindingofisaacrebirth.wiki.gg//wiki/Golden_Razor |
| 584 | Spindown Dice | Epic | Average difficulty | Defeat Delirium as Tainted Isaac | 474 | https://bindingofisaacrebirth.wiki.gg//wiki/Spindown_Dice |
| 585 | Hypercoagulation | Neutral | Average difficulty | Defeat Delirium as Tainted Magdalene | 475 | https://bindingofisaacrebirth.wiki.gg//wiki/Hypercoagulation |
| 586 | Bag of Crafting | Great | Average difficulty | Defeat Delirium as Tainted Cain | 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Bag_of_Crafting |
| 587 | Dark Arts | Good | Average difficulty | Defeat Delirium as Tainted Judas | 477 | https://bindingofisaacrebirth.wiki.gg//wiki/Dark_Arts |
| 588 | IBS | Bad | Hard | Defeat Delirium as Tainted ??? | 478 | https://bindingofisaacrebirth.wiki.gg//wiki/IBS |
| 589 | Sumptorium | Good | Average difficulty | Defeat Delirium as Tainted Eve | 479 | https://bindingofisaacrebirth.wiki.gg//wiki/Sumptorium |
| 590 | Berserk! | Neutral | Average difficulty | Defeat Delirium as Tainted Samson | 480 | https://bindingofisaacrebirth.wiki.gg//wiki/Berserk! |
| 591 | Hemoptysis | Good | Average difficulty | Defeat Delirium as Tainted Azazel | 481 | https://bindingofisaacrebirth.wiki.gg//wiki/Hemoptysis |
| 592 | Flip | Epic | Hard | Defeat Delirium as Tainted Lazarus | 482 | https://bindingofisaacrebirth.wiki.gg//wiki/Flip |
| 593 | Corrupted Data | Terrible | Insanely hard | Defeat Delirium as Tainted Eden | 483 | https://bindingofisaacrebirth.wiki.gg//wiki/Corrupted_Data |
| 594 | Ghost Bombs | Good | Insanely hard | Defeat Delirium as Tainted Lost | 484 | https://bindingofisaacrebirth.wiki.gg//wiki/Ghost_Bombs |
| 595 | Gello | Great | Average difficulty | Defeat Delirium as Tainted Lilith | 485 | https://bindingofisaacrebirth.wiki.gg//wiki/Gello |
| 596 | Keeper's Kin | Good | Insanely hard | Defeat Delirium as Tainted Keeper | 486 | https://bindingofisaacrebirth.wiki.gg//wiki/Keeper%27s_Kin |
| 597 | Abyss | Good | Average difficulty | Defeat Delirium as Tainted Apollyon | 487 | https://bindingofisaacrebirth.wiki.gg//wiki/Abyss |
| 598 | Decap Attack | Neutral | Hard | Defeat Delirium as Tainted Forgotten | 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Decap_Attack |
| 599 | Lemegeton | Great | Average difficulty | Defeat Delirium as Tainted Bethany | 489 | https://bindingofisaacrebirth.wiki.gg//wiki/Lemegeton |
| 600 | Anima Sola | Good | Insanely hard | Defeat Delirium as Tainted Jacob | 490 | https://bindingofisaacrebirth.wiki.gg//wiki/Anima_Sola |
| 601 | Mega Chest | Epic | Average difficulty | Defeat Mega Satan as Tainted Isaac | 58, 474 | https://bindingofisaacrebirth.wiki.gg//wiki/Mega_Chest |
| 602 | Queen of Hearts | Good | Average difficulty | Defeat Mega Satan as Tainted Magdalene | 58, 475 | https://bindingofisaacrebirth.wiki.gg//wiki/Queen_of_Hearts |
| 603 | Gold Pill | Good | Average difficulty | Defeat Mega Satan as Tainted Cain | 58, 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Pills |
| 604 | Black Sack | Great | Average difficulty | Defeat Mega Satan as Tainted Judas | 58, 477 | https://bindingofisaacrebirth.wiki.gg//wiki/Black_Sack |
| 605 | Charming Poop | Good | Average difficulty | Defeat Mega Satan as Tainted ??? | 58, 478 | https://bindingofisaacrebirth.wiki.gg//wiki/Charming_Poop |
| 606 | Horse Pill | Great | Average difficulty | Defeat Mega Satan as Tainted Eve | 58, 479 | https://bindingofisaacrebirth.wiki.gg//wiki/Pills |
| 607 | Crane Game | Epic | Average difficulty | Defeat Mega Satan as Tainted Samson | 58, 480 | https://bindingofisaacrebirth.wiki.gg//wiki/Crane_Game |
| 608 | Hell Game | Great | Average difficulty | Defeat Mega Satan as Tainted Azazel | 58, 481 | https://bindingofisaacrebirth.wiki.gg//wiki/Hell_Game |
| 609 | Wooden Chest | Great | Average difficulty | Defeat Mega Satan as Tainted Lazarus | 58, 482 | https://bindingofisaacrebirth.wiki.gg//wiki/Wooden_Chest |
| 610 | Wild Card | Great | Hard | Defeat Mega Satan as Tainted Eden | 58, 483 | https://bindingofisaacrebirth.wiki.gg//wiki/Wild_Card |
| 611 | Haunted Chest | Terrible | Hard | Defeat Mega Satan as Tainted Lost | 58, 484 | https://bindingofisaacrebirth.wiki.gg//wiki/Haunted_Chest |
| 612 | Fool's Gold | Epic | Average difficulty | Defeat Mega Satan as Tainted Lilith | 58, 485 | https://bindingofisaacrebirth.wiki.gg//wiki/Fool%27s_Gold |
| 613 | Golden Penny | Epic | Hard | Defeat Mega Satan as Tainted Keeper | 58, 486 | https://bindingofisaacrebirth.wiki.gg//wiki/Golden_Penny |
| 614 | Rotten Beggar | Great | Average difficulty | Defeat Mega Satan as Tainted Apollyon | 487 | https://bindingofisaacrebirth.wiki.gg//wiki/Rotten_Beggar |
| 615 | Golden Battery | Good | Average difficulty | Defeat Mega Satan as Tainted Forgotten | 58, 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Golden_Battery |
| 616 | Confessional | Great | Average difficulty | Defeat Mega Satan as Tainted Bethany | 58, 489 | https://bindingofisaacrebirth.wiki.gg//wiki/Confessional |
| 617 | Golden Trinket | Epic | Insanely hard | Defeat Mega Satan as Tainted Jacob | 58, 490 | https://bindingofisaacrebirth.wiki.gg//wiki/Golden_Trinket |
| 618 | Soul of Isaac | Epic | Average difficulty | Defeat Hush and Boss Rush as Tainted Isaac | 474 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Isaac |
| 619 | Soul of Magdalene | Neutral | Average difficulty | Defeat Hush and Boss Rush as Tainted Magdalene | 475 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Magdalene |
| 620 | Soul of Cain | Great | Average difficulty | Defeat Hush and Boss Rush as Tainted Cain | 476 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Cain |
| 621 | Soul of Judas | Bad | Average difficulty | Defeat Hush and Boss Rush as Tainted Judas | 477 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Judas |
| 622 | Soul of ??? | Bad | Average difficulty | Defeat Hush and Boss Rush as Tainted ??? | 478 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_%3F%3F%3F |
| 623 | Soul of Eve | Neutral | Average difficulty | Defeat Hush and Boss Rush as Tainted Eve | 479 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Eve |
| 624 | Soul of Samson | Neutral | Average difficulty | Defeat Hush and Boss Rush as Tainted Samson | 480 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Samson |
| 625 | Soul of Azazel | Epic | Average difficulty | Defeat Hush and Boss Rush as Tainted Azazel | 481 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Azazel |
| 626 | Soul of Lazarus | Neutral | Hard | Defeat Hush and Boss Rush as Tainted Lazarus | 482 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Lazarus |
| 627 | Soul of Eden | Epic | Hard | Defeat Hush and Boss Rush as Tainted Eden | 483 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Eden |
| 628 | Soul of the Lost | Great | Insanely hard | Defeat Hush and Boss Rush as Tainted Lost | 484 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_the_Lost |
| 629 | Soul of Lilith | Great | Average difficulty | Defeat Hush and Boss Rush as Tainted Lilith | 485 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Lilith |
| 630 | Soul of the Keeper | Good | Hard | Defeat Hush and Boss Rush as Tainted Keeper | 486 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_the_Keeper |
| 631 | Soul of Apollyon | Neutral | Average difficulty | Defeat Hush and Boss Rush as Tainted Apollyon | 487 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Apollyon |
| 632 | Soul of the Forgotten | Bad | Average difficulty | Defeat Hush and Boss Rush as Tainted Forgotten | 488 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_the_Forgotten |
| 633 | Soul of Bethany | Good | Average difficulty | Defeat Hush and Boss Rush as Tainted Bethany | 489 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Bethany |
| 634 | Soul of Jacob and Esau | Neutral | Insanely hard | Defeat Hush and Boss Rush as Tainted Jacob | 490 | https://bindingofisaacrebirth.wiki.gg//wiki/Soul_of_Jacob_and_Esau |
| 635 | A Strange Door | Good | Automatic | Defeat Mother | 405 | https://bindingofisaacrebirth.wiki.gg//wiki/A_Strange_Door |
| 636 | Death Certificate | Epic | Easy | Earn all Hard mode Completion Marks for all characters, including tainted ones | 276, 547, 491, 492, 493, 494, 495, 496, 497, 498, 499, 500, 501, 502, 503, 504, 505, 506, 507, 524, 525, 526, 527, 528, 529, 530, 534, 535, 536, 537, 539, 540, 541, 542, 543, 544, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634 | https://bindingofisaacrebirth.wiki.gg//wiki/Death_Certificate |
| 637 | Dead God | Neutral | Easy | Unlock all the other achievements and collect every item in the game | 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 235, 258, 323, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 339, 345, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 361, 362, 363, 364, 365, 366, 367, 368, 369, 371, 372, 373, 374, 375, 377, 378, 379, 380, 381, 382, 383, 384, 385, 387, 388, 389, 391, 406, 408, 409, 410, 412, 413, 414, 517, 518, 519, 520, 521, 522, 523, 531, 532, 533, 538, 545, 546, 582, 583, 636, 639, 640 | https://bindingofisaacrebirth.wiki.gg/# |
| 638 | Play Online | Neutral | Easy | Play an Online game | 0 | https://bindingofisaacrebirth.wiki.gg/# |
| 639 | Win Online | Neutral | Easy | Win an Online run | 638 | https://bindingofisaacrebirth.wiki.gg/# |
| 640 | Win Online Daily | Neutral | Easy | Win an Online Daily run | 638 | https://bindingofisaacrebirth.wiki.gg/# |